Scientific Study That Was Published in a Peer-reviewed Medical Journal Powdered Collagen
Collagen And Thyroid Relationship
Table of Contents
- 1 Sympathise What Collagen Is
- 2 The Importance Of Collagen In The Human being Body
- iii The Relationship Between The Thyroid Gland And Collagen
- three.1 Scientific Information On Thyroid Disorders And Collagen
- iv Conclusion
- 5 References
Concluding Updated on
Collagen is a type of protein family that has a number of of import roles to play in structures of the torso, including the pare, organs, and other tissues.
There are many unlike types of collagen that have been discovered. Collagen 2 marked significant importance for the medical science manufacture, discovered in 1969 by Miller and Matukas1. Since this time, at least 26 other types of collagen have as well been identified, bring the total number of these collagen molecules to more than 28 different types.
Some collagen types are more common than others. Collagen Ii in detail primarily makes up cartilage in the body, while blazon I is found in organs, tendons, bone tissue, and the skin.
Collagen type III is known as a reticulate type of collagen, blazon IV forms the basal lamina, and type V plays an important function in placenta, hair, and the surface of cells.
Even though a crucial component of many structures within the human body, collagen tin be unhealthy in some cases also, specially when a buildup of collagen occurs in certain regions.
In this article, we are examining the relationship that exists between the Thyroid gland, the secretion of Thyroid hormones, disorders that affect this item gland, and collagen throughout the body.
Understand What Collagen Is
Collagen, as previously noted, is a type of protein molecule. The protein molecule is fabricated from various combinations of amino acids. The primary goal of collagen molecules is to back up connective tissue – in particular, collagen is responsible for supporting the extracellular regions of the connective tissues that are institute within the human trunk.
Collagen is resistant to stretching and is a very rigid protein. This makes it the perfect structure support cloth for connectivity tissues similar ligaments, tendons, the pare, and, of course, basic.
Collagen is able to form a range of dissimilar structures – the structure'south class is used to classify collagen into specific groups. As mentioned previously, nearly 28 different types of collagen have already been identified.
An estimated 90% of all collagen that is found within the human trunk consists of type I collagen. The other most mutual types include Collagen Ii, Collagen III, and Collagen IVii.
Nearly collagen proteins in the body include one of the post-obit amino acrid chains/sequences:
- Glycine-10-hydroxyproline
- Glycine-proline-X
The X in the formula can exist replaced by 17 different amino acids. The specific formula or amino acid chain that makes up the collagen molecule determines its characteristics.
The Importance Of Collagen In The Human Torso
Collagen is important for the peel, for bones, muscle tissue, and many other parts of the human body. Different types of play roles in various areas of the torso.
Fifty-fifty though at that place are many products that promote collagen as a beneficial supplement, it should be noted that this is not an essential food that a person needs to swallow through foods and supplements. The body is capable of producing collagen itself.
It has, notwithstanding, been plant that the use of certain high-quality collagen supplements could assist in providing sure benefits to the man body.
In one written report3, scientists identified the potential of collagen supplements to assist in reducing the signs of aging associated with pare dryness, equally well as the formation of wrinkles.
In the medical industry, at that place are many potential applications for collagen. The poly peptide has been used to assist in the regeneration of bone tissue that has been damaged4. This holds potential for atmospheric condition that bear on the bones throughout the body, such as osteoporosis and arthritic conditions, where bone tissue becomes degenerated due to disease affecting basic.
This particular benefit regarding the effects of collagen on bones as well accounts for periodontal areas. In one study, information technology was found that collagen may exist useful in the regeneration in damaged ligament tissues inside the gums and jaws5.
Collagen has also been shown to be useful in the awarding where cartilage has become damaged due to injury or disease. A study showed that the use of a specialized collagen type might assist in the regeneration of the damaged cartilage, restoring cushioning for bones and jointshalf-dozen.
Furthermore, information technology should exist noted that collagen has likewise been found to be useful in the corrective industry.
In detail, collagen has been found to raise the moisturization of the skin significantly. Additionally, wrinkles tend to go reduced, and the protein seems to have a protective effect on sun-related damage and besides yields additional anti-aging benefits7.
The Relationship Between The Thyroid Gland And Collagen
The Thyroid gland is located inside the cervix – the gland secretes two very important hormones that do not only human activity on metabolism in the body but many other factors as well. The two hormones include Triiodothyronine, besides chosen T3, also as Thyroxin, or T4 for curt.
There are various conditions that may affect the Thyroid gland – and this can lead to two diseases. The two diseases that are relatively common in the general population include Hyperthyroidism and Hypothyroidism.
When a patient has hypothyroidism, the Thyroid's ability to function usually is commonly suppressed. The result is a refuse in the number of Thyroid hormones that are secreted into the blood circulatory system.
A patient with hyperthyroidism, on the other hand, will usually accept an excess number of these hormones being secreted into their bloodstream.
With hypothyroidism, metabolism becomes slower, but with hyperthyroidism, metabolism is increased. In addition to these potential complications, it is important to consider the fact that both of these conditions may atomic number 82 to additional complications in a patient'south body. Some of these effects may impact collagen in the body – leading to excessive production or a decline in the production of collagen.
Scientific Data On Thyroid Disorders And Collagen
Many studies have been performed to assist in providing evidence on how the secretion of Thyroid hormones, also equally the presence of certain Thyroid disorders, may affect the synthesis of collagen in the torso.
I study8 looked at how inducing hyperthyroidism and hypothyroidism affected collagen levels. The study was published in the Periodical of Endocrinology at Oxford Bookish. Below is a summary of the findings that are provided by the study.
- After inducing hypothyroidism and then injecting beast subjects with a proline solution, a type of amino acid that plays a large role in the synthesis of collagen, it was found that levels of collagen in various parts of the body may be reduced. This includes collagen in bones. Urine levels of hydroxyproline were significantly lower too – lower than the level of hydroxyproline levels detected in bone tissue.
- When rat subjects were treated with thyroxine and and then injected with a solution containing proline amino acids were institute to exhibit a reduction in hydroxyproline activity in the peel. On the other hand, hydroxyproline activity in urine samples was increased.
Even though conducted on animal subjects, this study provided show that Thyroid hormones take a definite upshot on collagen production and the activity of amino acids that are involved in the germination of collagen.
With the presence of hypothyroidism, levels of collagen in bone tissue may be reduced. This could exist a potential reason behind the fact that patients diagnosed with hypothyroidism is considered at a college take a chance of bone fractures, as well as weather such as osteoporosis.
Furthermore, several changes in the activity of collagen-related amino acids were as well seen in cases where thyroxine was administered to written report subjects. The injection of thyroxin is likely to induce a state of hyperthyroidism.
A scientific paperix published in the Japanese Periodical of Clinical Pathology monitored the furnishings of hyperthyroidism on collagen levels. The study analyzed in the newspaper primarily focused on how hyperthyroidism, existence an overactive Thyroid gland, would affect the level of collagen type Iv in the body of 104 human subjects.
The study used an enzyme immunoassay test and tested for two specific antibodies that are recognizable by the seven-S domain, every bit well as triple-helical, in order to make up one's mind levels of collagen type Four. After studying, the results of collagen 4 levels in hyperthyroidism patients were compared to levels of this collagen in patients without hyperthyroidism.
Levels of collagen IV was significantly college – there was also a correlation between collagen type Iv levels and Thyroid hormone levels. As Thyroid hormones increased, and so did levels of collagen blazon IV.
When patients with hyperthyroidism were treated using antithyroid drugs in social club to bring downwards the overactivity of their Thyroid gland, it was establish that collagen type Four levels returned to normal as well.
It should exist noted that levels of collagen IV were non reduced to significantly low levels among patients who had hypothyroidism. Furthermore, the scientists behind the study likewise noted that when patients with hypothyroidism were treated with levothyroxine medication, there was an elevation in the production of collagen IV in the patients.
This makes it complicated to care for hypothyroidism in patients when collagen product may be a particular business organization. An excellent case would be in cases where a patient may be at risk of liver disease – such as when the particular patient had previously been diagnosed with fatty liver disease.
Collagen plays a office in fibrosis – and when levels of collagen are increased too greatly in the trunk, then there might be a higher risk of fibrosis becoming more astringent.
Conclusion
Collagen has many of import roles in the homo body and is found in most tissues. An increase in certain collagen types, however, may lead to an increased run a risk of fibrosis and other potential complications, while a decline in collagen may also cause a number of possible issues to ascend.
The well-being of the Thyroid may have an touch on collagen levels, as studies take found that regulating the release of Thyroid hormones may exist beneficial for also balancing collagen in the body, and may even yield a protective effect in certain cases.
References
1 R.B. Sylvie. The Collagen Family. Journal of Common cold Spring Harbor: Perspectives in Biology. Jan 2011. https://www.ncbi.nlm.nih.gov/pmc/manufactures/PMC3003457/
2 G. Wu, J.S. Crane. Biochemistry, Collagen Synthesis. StatPearls. 27 Oct 2018. https://world wide web.ncbi.nlm.nih.gov/books/NBK507709/
3 One thousand. Borumand, S. Sibilla. Daily consumption of the collagen supplement Pure Aureate Collagen reduces visible signs of crumbling. Dovepress: Clinical Interventions in Aging. 13 Oct 2014. https://world wide web.ncbi.nlm.nih.gov/pmc/articles/PMC4206255/
4 B. Hoyer, A. Bernhardt, S. Heinemann, I Stachel, Grand. Meyer, M. Gelinsky. Biomimetically mineralized salmon collagen scaffolds for awarding in os tissue engineering. Journal of Biomacromolecules. nine Apr 2012. https://www.ncbi.nlm.nih.gov/pubmed/22364350/
5 N. Nagai, S. Yunoki, T. Suzuki, M. Sakata, Thou. Tajima, M. Munekata. Application of cross-linked salmon atelocollagen to the scaffold of man periodontal ligament cells. Journal of Bioscience and Bioengineering. 2004. https://www.ncbi.nlm.nih.gov/pubmed/16233648/
half-dozen B. Hoyer, A. Bernhardt, A. Lode, Southward. Heinemann, J. Sewing, M. Klinger, H. Notbohm, M. Gelingsky. Jellyfish collagen scaffolds for cartilage tissue engineering. Periodical of Acta Biomaterialia. thirty Oct 2013. https://world wide web.ncbi.nlm.nih.gov/pubmed/24184178/
7 E. Xhauflaire-Uhoda, K. Fontaine, Thousand.Eastward. Pierard. Kinetics of moisturizing and firming furnishings of cosmetic formulations. International Periodical of Cosmetic Scientific discipline. Apr 2008. https://www.ncbi.nlm.nih.gov/pubmed/18377622/
8 K.I. Kivirikko, O. Laitinen, J. Aer, J. Halme. Metabolism of Collagen in Experimental Hyperthyroidism and Hypothyroidism in the Rat. Endocrine Lodge: Periodical of Endocrinology. 1 Jun 1967. https://academic.oup.com/endo/article-abstruse/lxxx/6/1051/2695961?redirectedFrom=fulltext
nine Y. Senda, M. Nishibu, M. Kawai, Y. Mizukami, T. Hashimoto. Evaluation of type IV collagen in patients with diverse thyroid disease. Rinsho Byori: The Japanese Periodical of Clinical Pathology. December 1993. https://www.ncbi.nlm.nih.gov/pubmed/8295344
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